Step 1: Consultation A practitioner will assess your symptoms, lifestyle, and medical background to determine suitability
Homocysteine Elevated homocysteine is a risk factor for cardiovascular disease, and folate, B12 and vitamin B6 have been shown to reduce homocysteine levels
At the molecular level, 5-amino-1MQ functions as a competitive inhibitor of NNMT, demonstrating remarkable potency with an IC of 1.2 0.1 M under standard assay conditions (50 M SAM, 100 M nicotinic acid). This represents a dramatic 10-fold improvement over the parent compound 1-methylquinolinium, achieved through strategic amino group substitution that enhances binding affinity to the NNMT active site. The compound's mechanism centers on preventing the methylation of nicotinamide to 1-methylnicotinamide (1-MNA), thereby preserving nicotinamide for recycling back to NAD+ through the salvage pathway. This intervention effectively blocks what researchers have termed the "NNMT metabolic drain" a process that simultaneously depletes NAD+ precursors and consumes cellular methylation capacity
The primary reasons people become deficient usually fall into two categories: Dietary Factors: Since B12 is mainly found in animal products (meat, fish, dairy, eggs), vegans and strict vegetarians are particularly susceptible if they dont consume fortified foods or specific supplements
